Randomized trial on fluorides and sealants for fissure caries prevention.
نویسندگان
چکیده
To investigate the effectiveness of topical fluorides in preventing fissure caries, we conducted a randomized controlled trial with parallel groups. In total, 501 children (1,539 molars, 3,078 sites), mean age 9.1 years, who had at least one sound permanent first molar with deep fissures or fissures with signs of early caries were recruited. They were randomly allocated among four groups: (1) resin sealant, single placement; (2) 5% NaF varnish, semi-annual application; (3) 38% silver diamine fluoride (SDF) solution, annual application; and (4) placebo control. Follow-up examinations were conducted every 6 months by a masked examiner. After 24 months, 485 children (97%) were examined. Proportions of pit/fissure sites with dentin caries in the sealant, NaF, SDF, and control groups were 1.6%, 2.4%, 2.2%, and 4.6%, respectively. A multi-level logistic regression analysis accounting for the effects of data clustering and confounding factors showed that fissures in any of the three treatment groups had significantly lower risks of carious cavity development into dentin than did controls (p < 0.05). We concluded that placement of resin sealant, semi-annual application of NaF varnish, and annual application of SDF solution are all effective in preventing pit and fissure caries in permanent molars (ClinicalTrials.gov number CT01446107).
منابع مشابه
The use of pit and fissure sealants in dentistry, present status and future developments.
becoming available, as well as results from long-term clinical trials, a great deal of evidence has accumulated to support the clinical efficacy of pit and fissure sealants. Since smooth surfaces benefit most, and occlusal surfaces the least from the use of fluorides, an alternative technique which prevents occlusal caries can make a major impact on overall caries reduction when used in conjunc...
متن کاملDental Caries – A Strategic approach for prevention
Dental caries is a chronic, bio-behavioural disease that extends throughout the life span of human beings. Prevention of dental caries includes measures to prevent the occurrence of disease, such as risk factor reduction, but also to arrest the progress of disease and reduce consequences of the disease once it is established. Preventive measures like fluoride therapy and pit and fissure sealant...
متن کاملGlass ionomer ART sealant and fluoride-releasing resin sealant in fissure caries prevention – results from a randomized clinical trial
BACKGROUND The relative performance of ART sealant and fluoride-releasing resin sealant in preventing fissure caries in permanent molars was compared in a randomized clinical trial conducted in southern China (ClinicalTrials.gov NCT01829334). METHODS After obtaining ethical approval, healthy schoolchildren who had permanent first molars with occlusal fissures which were sound but deep or pres...
متن کاملEvidence of Effectiveness of Current Therapies to Prevent and Treat Early Childhood Caries.
PURPOSE The purpose of this paper was to systematically review the quality of evidence related to self-applied and professionally applied fluorides, antimicrobial agents, fissure sealants, temporary restorations, and restorative care for the prevention and management of early childhood caries (ECC). METHODS Relevant papers were selected after an electronic search for literature published in E...
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ورودعنوان ژورنال:
- Journal of dental research
دوره 91 8 شماره
صفحات -
تاریخ انتشار 2012